Further, CFD simulation prediction of the temperature profile in the bottled beer was validated with experimental measurements. The study was extended to investigate the effects of different zones' temperatures on inactivation of Saccharomyces cerevisiae, the most common beer spoilage organism. A tunnel pasteurizer with seven zones was selected to study the temperature profile inside the bottled beer and found to be in good agreement with the published temperature profiles in different zones. In addition, the effectiveness of pasteurization was investigated in terms of pasteurization unit (PU) and the resultant PU value (15 to 30 PU) was adequate for achieving the maximum sterility of beer.