In the mixed patient study, within the early-good and delayedpartial
trajectory groups, the profiles of response to clozapine
and chlorpromazine appeared similar (Figure 3). The earlygood
trajectory group showed an initial steep decline, with
later attenuation in response over the 4 weeks of the study;
while the delayed-partial trajectory group appeared to be
slow to respond initially, but was still improving at the end
of 4 weeks. In the refractory-patient study, the profiles of
response to clozapine and chlorpromazine appeared slightly
different. In the early-good trajectory group, clozapinetreated
patients appeared to be continuing to improve at the
end of 6 weeks (mean BPRS item change 49.2%), while
the treatment response in chlorpromazine-treated patients
appeared to be attenuating (mean BPRS item change 21.0%).
The delayed-partial trajectory group showed a modest initial
response, which attenuated for both drugs.
Focusing on the clozapine-treated patients (Figure 4),
putative clozapine-resistant patients were observed in both
the mixed- (10/50, 20.0%) and the refractory- (35/122,
28.9%) patient studies.