extract and their isorhamnetinglycosides, IGRR and IGR exhibited significant anti-inflammatory potential through different mechanisms of action such as the sup-pression of cellular infiltration, inhibiting both the production of nitric oxide and activity of COX-2, and decreased secretion of cytokines. Also, we demonstrated that the anti-inflammatory effect was greater with the OFI extract treatment probably because the synergistic effects of their phytochemicals. However, we can only speculate that the effect observed with the OFI extract is mainly dueto synergistic effect between isorhamnetin glycosides, particularly isorhamnetin triglycosides.