more typical AOS. All publishedneurobiological risk factors wereexamined carefully in patients withCOS. As expected, COS showed asimilar yet exaggerated pattern ofrisk factors that may have reflectedgreater impairment in early braindevelopment, but also supported thecontinuity between COS and AOS.These observations included higherrates of early developmental abnormalities(language, social, and motordomains), larger effect sizes forsmooth pursuit eye movement abnormalities,and higher incidence offamilial schizophrenia spectrumdisorders.