This study showed that cryogenic freezing resulted in better quality catfish fillets than the air blast freezing. Especially, the cryogenically frozen catfish had lower lipid oxidation development than air blast frozen fillets during frozen storage. In addition, cryogenic freezing exhibited many advantages including high freezing rates and shorter freezing times, ease of operation and control, and very low modification of catfish fillets quality characteristics as measured by instrumental analysis. Cryogenic freezing produced catfish fillets with the best color values and less production of secondary oxidation products than blast freezing. The data obtained in this research for freezing time and freezing rates for freezing catfish could be useful to scale up the process.