In TCM theory, the clinic presentations of acute leukemia, such as fever, bleeding, anemia, hepatomegaly, splenomegaly, or lymphadenopathy, are related to the process of virtual essence with Heat-evil entering nutrient-blood. When it comes to the refractory stage of leukemia, the Heat-evil will burn out the yin-blood of the liver and kidney, further unbalancing the yin-yang. We believe repeated and external Toxin-evil (i.e., anthracycline) may increase the oxidative stress of cardiomyocytes; in otherwords, they may aggravate the burden of Heart-yang, giving purge retention of blood-stasis and fluid from the Lung. At that time, Bai Shao, Mu Li, Bie Jia, and Gui Ban can be sequentially added on the basis of ZGCT to help recuperate yang, clean heat and nourish yin, and purge retention of fluid from the Heart and Lung. Application of modified ZGCT in treating chemotherapy-induced CHF in patients with refractory ALL could elevate the clinical efficacy, which is of great value in clinical practice.