1)Virus enters injured cells.
2) Ribosomes strip off coat and
begin to translate the RdRp.
3) RdRp binds to the tRNA-like
3’ end & initiates synthesis of
minus strands to form RI
RNA.
4) Plus-strand genomic RNAs &
the movement protein (MP) &
coat protein (CP) sgRNAs are
synthesized.
5) MP & CP are translated.
6) MP forms complexes with newly synthesized viral RNA & membranes.
The complex moves through plasmodesmata to adjacent cells.
7) CP & genomic RNAs accumulate to very high levels and virus crystals
accumulate in the cytoplasm. Double-strand replicative form (RF) RNA
accumulates in the cell and elicits host gene silencing responses.
8) Replication is very highly regulated but many details are not yet known.