Background
Miscarriage is the most common complication in pregnancy with an incidence of 12–31%.[1] In South Africa it contributes to 30% of "pregnancy related sepsis" and is directly responsible for 3.5% of all maternal deaths.[2] Recurrent pregnancy loss (RPL) is defined as the loss of three or more consecutive pregnancies before 20 weeks gestation and is estimated to affect 1% of all couples trying to conceive.[3,4]