We reasoned that, in mice immunized with rLm-gp33, the strong epitope-specific response may cause a selection for virus lacking the gp33 epitope and that, since gp33 is expressed as a fusion protein with EGFP, there may be a loss of EGFP as well.
We reasoned that, in miceimmunized with rLm-gp33, the strong epitope-specific responsemay cause a selection for virus lacking the gp33 epitopeand that, since gp33 is expressed as a fusion protein withEGFP, there may be a loss of EGFP as well.