Lithium modified bioactive glass nanoparticles were prepared for multiple deliveries of lithium ions and drugs . Also, lithium ions were released from glass nanoparticles via diffusion controlled process which could activate Wnt signaling pathway and enhance osteogenesis . As a final point, the possibility of utilizing the glass nanoparticles as a controlled delivery device for vancomycin or 5-FU was verified. Fitting vancomycin or 5-FU release profiles to various mathematical models pointed out that both drugs were released by a diffusion-controlled mode.