The most important question concerns the safety of applying microbial cleaning as biocontrol system in healthcare facilities. Obviously the identification and safety assessment of the bacterial strains used in the products is of utmost importance, as well as the production processes involved throughout the whole production chain. The strains used in this study (Bacillus subtilis, Bacillus pumilus and Bacillus megaterium), were food grade organisms, for which substantial safety and toxicity data existed by the manufacturer, and are also known to be not harmful to humans. In addition, all production and quality control processes were ISO9001:2008 certified. Furthermore, the use of probiotics for several biotechnological and biopharmaceutical applications, as indicated by the very recent employment of B. subtilis as a
biocontrol agent in aquaculture, agriculture, as adjuvant or, in the spore form, as delivery system for development of new vaccines has been subject to study and control.