Continuous use of mineral fertilizer in tropical soils is associated with reduced crop yield, increased soil acidity and nutrient imbalance. A combination of organic materials and mineral fertilizer is better fertilizer management for these soils. Approach:Performance of Okra (Abelmoschus esculentus L Moench) was assessed using synthetic NPK fertilizer alone, organic materials alone, or a mix of the two. Results:Application of 60 kg N + 2.5 Mt·ha-1 organic fertilizer produced the tallest plants, 57 cm. Application of 60 kg N + 2.5 Mt·ha-1 poultry manure (PM) and with Gliricidia leaves produced plants of 53 and 51 cm, respectively. Stem circumference and leaf area followed the same trend. Application of 60 kg N + 2.5 Mt·ha-1 Organic-based Fertilizer (OBF) produced the highest yield, 3.58 Mt·ha-1 which was similar to 3.29 and 3.20 Mt·ha-1 from applications of 60 kg N + 2.5 Mt·ha-1 PM and Gliricidia leaves, respectively. Okra leaf N and P contents were increased by 37 and 130% respectively, with Gliricidia leaves. Conclusion: Complementary application of 2.5 tonnes OBF and 60kg N as NPK 20-10-10 most favoured Okra growth and yield. [M.O. Akande, F.I. Oluwatoyinbo, E.A. Makinde, A.S. Adepoju and I.S. Adepoju. Response of Okra to Organic and Inorganic Fertilization. Nature and Science 2010;8(11):261-266] (ISSN: 1545-0740