INTRODUCTION
Relatively few scholars would question that we live in an era of unmet One Health challenges. Humans, domestic and wild animals, and plants concurrently suffer impacts from emerging and re-emerging infections, toxicant exposures, environmental mismanagement, climate change, warfare, economic and political failings, and a lack of expertise needed to implement the needed solutions. But, many would question why societies fail to identify and counteract such phenomena earlier and more effectively. Many would ask what efforts demonstrate promise in One Health surveillance now and whether they can be applied more broadly. No doubt, a great many would inquire as to how future generations can reliably organize their systems of education, professional interactions, governance, incentives, and disincentives to create a world characterized by steady gains in One Health. Here we endeavor to offer answers to these open questions.