Air quality plays an important role in occupational and environmental medicine and many airborne factor negatively influence human health [1-6]. This review summarizes recent data on car indoor air quality published by research groups all over the world. It also refers to formerly summarized established knowledge concerning air pollution. Air pollution is the emission of toxic elements into the atmosphere by natural or anthropogenic sources. These sources can be further differentiated into either mobile or stationary sources. Anthropogenic air pollution is often summarized as being mainly related to motorized street traffic (especially exhaust gases and tire abrasion). Whereas other sources including the burning of fuels, and larger factory emissions are also very important, public debate usually addresses car emissions.