Figure 2. Effect of fetal alcohol exposure on fetal cerebral artery Doppler indices during alcohol exposure. A, Average changes in anterior cerebral artery (ACA) peak systolic velocity (PSV) and pulsatility index (PI) by repeated alcohol exposure. Data are normalized to the values that were obtained immediately before the infusion of control or alcohol-containing drink. Zero level represents no change in the measured parameter as observed at 120 minutes following the infusion of the assigned drink as compared to the preinfusion level in each group. Changes in the positive direction reflect increases in the measured parameter upon drink infusion, whereas changes in the negative direction are equivalent to decreases in the measured parameter upon drink infusion. Here and in B, *statistically significant difference in changes in fetal artery function parameters in response to maternal gastric infusion of control versus alcohol-containing solution, P < .05. B, Middle cerebral artery data; annotation is similar to A.