Sudden elevations in the hepatic enzymes were observed
around the 7th postoperative day,without any impeded blood
flow, including outflow block; therefore, acute rejection was
highly suspected. As temporal dose increments of steroid and
MMF were appropriately administered, liver function gradually
improved.The patient recovered progressively without
any other complications, and the protocol liver biopsy on
postoperative day 30 revealed no evidence of rejection, HCV
relapse, and HBV infection. She was discharged from the
hospital on postoperative day 39.
During the outpatient followup, MMF and tacrolimus
were converted to mizoribine and cyclosporine from the
viewpoint of the inhibition of HCV ribonucleic acid (HCVRNA)
replication and possibility of administration of pegylated
interferon-