Extremophilic microbes (extremophiles) abound in extreme habitats, and include acidophiles (acidic sulfurous
hot springs), alkalophiles (alkaline lakes), halophiles (salt
lakes), piezo (baro)- and (hyper)thermophiles (deep-sea
vents),78-82 and psychrophiles (arctic and antarctic waters,
alpine lakes).83 While research has centered on the isolation
ofthermophilicandhyperthermophilicenzymes(extremozymes),84-88
there is little doubt that these extreme environments will also
yield novel bioactive small molecule chemotypes. Unusual
acidophiles that thrive in the acidic, metal-rich waters,
polluted environments have been isolated from abandoned
mine-waste disposal sites that are generally toxic to most
prokaryotic and eukaryotic organisms.89 Penicillium species
found in the contaminated surface waters of Berkeley Pit
Lake in Montana have yielded the novel sesquiterpenoid and
polyketide-terpenoid metabolites, berkeleydione (27, Scheme
7), berkeleytrione (28; Scheme 7), and berkeleyamides A-D
(29-32; Scheme 7)
Extremophilic microbes (extremophiles) abound in extreme habitats, and include acidophiles (acidic sulfurous
hot springs), alkalophiles (alkaline lakes), halophiles (salt
lakes), piezo (baro)- and (hyper)thermophiles (deep-sea
vents),78-82 and psychrophiles (arctic and antarctic waters,
alpine lakes).83 While research has centered on the isolation
ofthermophilicandhyperthermophilicenzymes(extremozymes),84-88
there is little doubt that these extreme environments will also
yield novel bioactive small molecule chemotypes. Unusual
acidophiles that thrive in the acidic, metal-rich waters,
polluted environments have been isolated from abandoned
mine-waste disposal sites that are generally toxic to most
prokaryotic and eukaryotic organisms.89 Penicillium species
found in the contaminated surface waters of Berkeley Pit
Lake in Montana have yielded the novel sesquiterpenoid and
polyketide-terpenoid metabolites, berkeleydione (27, Scheme
7), berkeleytrione (28; Scheme 7), and berkeleyamides A-D
(29-32; Scheme 7)
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Extremophilic microbes (extremophiles) abound in extreme habitats, and include acidophiles (acidic sulfurous
hot springs), alkalophiles (alkaline lakes), halophiles (salt
lakes), piezo (baro)- and (hyper)thermophiles (deep-sea
vents),78-82 and psychrophiles (arctic and antarctic waters,
alpine lakes).83 While research has centered on the isolation
ofthermophilicandhyperthermophilicenzymes(extremozymes),84-88
there is little doubt that these extreme environments will also
yield novel bioactive small molecule chemotypes. Unusual
acidophiles that thrive in the acidic, metal-rich waters,
polluted environments have been isolated from abandoned
mine-waste disposal sites that are generally toxic to most
prokaryotic and eukaryotic organisms.89 Penicillium species
found in the contaminated surface waters of Berkeley Pit
Lake in Montana have yielded the novel sesquiterpenoid and
polyketide-terpenoid metabolites, berkeleydione (27, Scheme
7), berkeleytrione (28; Scheme 7), and berkeleyamides A-D
(29-32; Scheme 7)
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