In patients with T2DM, the evidence base is simply too
small to prove (or disprove) efficacy of ADM or psychotherapy
for relief or remission of depression. Clinical
equipoise exists and will persist until more studies specific
to patients with comorbid depression and T2DM become
available. These studies should be sufficiently powered to
detect both treatment-related and treatment-independent
effects of depression improvement on glycemic control and
the prognosis of diabetes