DENV infection does indeed
change the protein profile of human plasma [6–13], and although this
phenomenon may simply be part of the antiviral response of the host,
it might also arise from the sequestration of certain plasma components
due to direct interactions with DENV proteins such as prM, E and NS1,
which exhibit sequence similarities with a number of coagulatory
molecules and membrane proteins of platelets and endothelial cells