Abstract
This paper investigates the possibility of computerised diagnosis of malaria
and describes a method to detect malaria parasites (Plasmodium spp) in images
acquired from Giemsa-stained peripheral blood samples using conventional
light microscopes. Prior to processing, the images are transformed to
match a reference image colour characteristics. The parasite detector utilises
a Bayesian pixel classifier to mark stained pixels. The class conditional probability
density functions of the stained and the non-stained classes are estimated
using the non-parametric histogram method. The stained pixels are
further processed to extract features (histogram, Hu moments, relative shape
measurements, colour auto-correlogram) for a parasite/non-parasite classi-
fier. A distance weighted K-nearest neighbour classifier is trained with the
extracted features and a detailed performance comparison is presented. Our
method achieves 74% sensitivity, 98% specificity, 88% positive prediction,
and 95% negative prediction values for the parasite detection.
AbstractThis paper investigates the possibility of computerised diagnosis of malariaand describes a method to detect malaria parasites (Plasmodium spp) in imagesacquired from Giemsa-stained peripheral blood samples using conventionallight microscopes. Prior to processing, the images are transformed tomatch a reference image colour characteristics. The parasite detector utilisesa Bayesian pixel classifier to mark stained pixels. The class conditional probabilitydensity functions of the stained and the non-stained classes are estimatedusing the non-parametric histogram method. The stained pixels arefurther processed to extract features (histogram, Hu moments, relative shapemeasurements, colour auto-correlogram) for a parasite/non-parasite classi-fier. A distance weighted K-nearest neighbour classifier is trained with theextracted features and a detailed performance comparison is presented. Ourmethod achieves 74% sensitivity, 98% specificity, 88% positive prediction,and 95% negative prediction values for the parasite detection.
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