stimuli and by the impairment of the skin barrier’s
ability to repair itself. Several lines of evidence suggest that
beyond their capacity to positively influence the composition of
intestinal microbiota, some probiotic bacteria can modulate the
immune system both at local and systemic levels, thereby
improving immune defense mechanisms and ⁄ or down-regulating
immune disorders such as allergies and intestinal inflammation.
Several recent human clinical trials clearly suggest that probiotic
supplementation might be beneficial to the skin. Using a probiotic
lysate, Bifidobacterium longum sp. extract (BL), we demonstrated
first in vitro, and then in a clinical trial, that this non-replicating
bacteria form applied to the skin was able to improve sensitive
skin. The effect of BL were evaluated first on two different
models.