As an important aspect of nanotechnology, nanoparticles (NPs, less than 100 nm in one dimension) have been developed for a variety of applications, especially in the area of nanomedicine (1). NPs possess characteristic properties that differ from those of their bulk counterparts. In the area of nanomedicine, NPs are commonly employed as drug delivery vehicles. Recently, NPs have been employed in therapeutic applications to target specific sites, such as lung tissue, as well as in cancer therapy and vaccinations (1). Additionally, the use of NPs continues to increase in microbial applications due to the potential of NPs to circumvent microbial resistance while satisfying the current need for novel antibiotics (2-4). The number of infections and outbreaks associated with multi-drug-resistant (MDR) bacteria has increased, threatening public health. The NPs used to overcome microbial resistance include nitric oxide-releasing NPs, chitosan NPs and metallic NPs (3). Among the metallic NPs, the medicinal potentials of gold NPs (AuNPs) and silver NPs (AgNPs) have been extensively discussed elsewhere (5). AgNPs possess excellent antibacterial, antiviral and antifungal activities (6). Metallic NPs are commonly synthesized by traditional chemical and physical methods (7). However, current sustainability issues have led to explorations of eco-friendly synthesis and green synthesis for the production of metallic NPs based on diverse biological entities (7). This review is not meant to be inclusive of all plant extracts utilized for the green synthesis of AgNPs. There are extensive reviews that address this area (8-12). Instead, this review focuses on the preparation of antibacterial AgNPs by using plant extracts as reducing agents.