simplex virus 1 (HSV-1) (Wiart et al. 2005). The A. paniculata ethanol extract and andrographolide inhibit the expression of Epstein-Barr virus (EBV) (Lin et al. 2008). A recent in vitro study investigated the anti-influenza activity of A. paniculata in canine kidney cell line infected with H1N1, H9N2, or H5N1 (Chen et al. 2009). Andrographolide and their derivatives displayed anti-HIV activity in vitro by inhibiting gp120-mediated cell fusion of HL2/3 cells (expressing gp120 on its surface) with TZM-bl cells (expressing CD4 and co-receptors CCR5 & CXCR4) (Uttekar et al. 2012