Drug resistance in TB remains a man-made phenomenon. It emerges as a result of spontaneous gene mutations in M. tuberculosis that render the bacteria resistant to the most commonly used anti-TB drugs. Among the reasons for this, the non-compliance with the treatment regimens is signaled as the first cause. The standard treatment of TB calls for a six-month regimen of four drugs that in the case of MDR-TB is extended to 18–24 months involving second-line drugs. This makes compliance with the treatment regimens very challenging and the rates of non-adherence could be high, resulting in poor outcomes and further dissemination of MDR strains.