Clinical manifestation
and disease severity are results of a combination of factors
including the pathogen’s virulence factors, inoculum size,
and characteristics of host immunity. An initial, localized lesion
in the subcutaneous tissue may appear at the site of
trauma, which may evolve to a form that disseminates along
the local lymphatic system. Patients with impaired immunity
can develop aggressive forms. These features are observed
with species in the clinical clade, however, environmental
species may also cause human sporotrichosis, upon contact
with the host, the innate and acquired immunity normally resolve
the infection
Clinical manifestationand disease severity are results of a combination of factorsincluding the pathogen’s virulence factors, inoculum size,and characteristics of host immunity. An initial, localized lesionin the subcutaneous tissue may appear at the site oftrauma, which may evolve to a form that disseminates alongthe local lymphatic system. Patients with impaired immunitycan develop aggressive forms. These features are observedwith species in the clinical clade, however, environmentalspecies may also cause human sporotrichosis, upon contactwith the host, the innate and acquired immunity normally resolvethe infection
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