momordica cochinchinensis Spreng is commonly called “Gac fruit” which is an edible plant using as herbal medicine. It is grown in many Asian countries, including China, Cambodia, Japan, Thailand,Laos and Malaysia.1,2 Gac fruits are large, densely aculaeate, and green, turning to dark orange or red when ripe. Unripe fruits were used for cooking while ripe fruit were used to pharmaceutical and food product application. Because ripe fruit as amount beta carotene and lycopene higher than any other fruit and vegetable of all kinds2-5 and most studies have focused on ripe gac fruit.2-5 By considering the fact found that unripe gac fruit is very popular to use as food by scald and boil. It was eaten with chili sauce or taken sour curry (Gaeng Liang) and sour soup (Gaeng Som) in Thailand.2 To provide the study about gac fruit has increase comprehensive.Therefore, the aims of this study were to: (1) evaluate and compare the total antioxidant capacity by four antioxidant activities method, including total phenolics and flavonoids content, DPPH radical scavenging activity and ferric ion reducing antioxidant power assay; (2) study and compare the antibacterial activities against six human pathogenic strains by agar disc diffusion assay and broth macro dilution method (MIC and MBC) from each part of unripe and ripe gac fruit extracts (peel, pulp and aril) in different solvents such as methanol, acetone, hexane as well as and gac juice (water) in order to guideline for the use of antioxidant and antibacterial agents or reducing the risk of disease by food in the future.