The presence of a thymine dimer
blocks replication, but DNA
polymerase can bypass the lesion and can bypass the lesion and
reinitiate replication at a new site
downstream of the dimer.
The result is a gap opposite the dimer
In recombinational repair this gap
The result is a gap opposite the dimer
in the newly synthesized DNA strand.
In recombinational repair, this gap
is filled by recombination with the
undamaged parental strand.
The gap can be filled by the actions The gap can be filled by the actions
of polymerase and ligase, using the
intact daughter strand as a
template.
Two intact DNA molecules are thus
formed, and the remaining thymine
dimer eventually can be removed
Lect. Dr. Jintana Yanola, AMS, CMU, Thailand 3/25/2014
by excision repair
The presence of a thymine dimer
blocks replication, but DNA
polymerase can bypass the lesion and can bypass the lesion and
reinitiate replication at a new site
downstream of the dimer.
The result is a gap opposite the dimer
In recombinational repair this gap
The result is a gap opposite the dimer
in the newly synthesized DNA strand.
In recombinational repair, this gap
is filled by recombination with the
undamaged parental strand.
The gap can be filled by the actions The gap can be filled by the actions
of polymerase and ligase, using the
intact daughter strand as a
template.
Two intact DNA molecules are thus
formed, and the remaining thymine
dimer eventually can be removed
Lect. Dr. Jintana Yanola, AMS, CMU, Thailand 3/25/2014
by excision repair
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