A: estimated final α-tocopherol concentration (μg/g tissue); B: maximum α-tocopherol concentration increase/vitamin E dose (μg/g tissue/IU); C: vitamin E dose at maximum α-
tocopherol concentration increase (IU); BE: maximum α-tocopherol concentration increase (μg/g tissue) at dose 0 (IU); CE: initial α-tocopherol concentration (μg/g tissue). SE:
standard error of estimation; εij: the residual value of ith experiment at jth dose level; uij: variance of random effect of ith experiment at jth dose level. x random effect in parameter A;
y random effect in parameter C.