Depending on the chosen solvents, this media can also separate sample components by partition between the stationary and mobile phases.Sephadex LH-20 is useful at both analytical and industrial scale for the preparation of closely related molecular species. Due to the unique physico-chemical properties of this media, it can be used either during initial purification prior to polishing by high performance ion exchange or reversed phase chromatography or as the final polishing step e.g. during the preparation of diastereomers