The association held “quite consistently” and was “very” statistically significant, Finlay says. In addition to differences in stool bacteria, the team found differences in the urine of the babies who went on to develop asthma. Certain bacterial byproducts were at lower or higher levels, hinting that these chemicals—produced in the gut but distributed throughout the body—could act on the immune system to make it more susceptible to the disease.
Next, Finlay’s group used stool samples from the asthma-prone 3-month-olds to colonize the guts of mice that had been raised in a bacteria-free environment. The animals went on to develop inflamed lungs indicative of asthma. But if the researchers added a mixture of the four missing microbes to the mice’s digestive tracts along with the feces, the mice no longer had a heightened risk of developing asthma, the scientists report online today in Science Translational Medicine.
The association held “quite consistently” and was “very” statistically significant, Finlay says. In addition to differences in stool bacteria, the team found differences in the urine of the babies who went on to develop asthma. Certain bacterial byproducts were at lower or higher levels, hinting that these chemicals—produced in the gut but distributed throughout the body—could act on the immune system to make it more susceptible to the disease.Next, Finlay’s group used stool samples from the asthma-prone 3-month-olds to colonize the guts of mice that had been raised in a bacteria-free environment. The animals went on to develop inflamed lungs indicative of asthma. But if the researchers added a mixture of the four missing microbes to the mice’s digestive tracts along with the feces, the mice no longer had a heightened risk of developing asthma, the scientists report online today in Science Translational Medicine.
การแปล กรุณารอสักครู่..