Conclusions
Our results confirmed that the aqueous extract of B. orellana had antihistamine activities, as demonstrated
by the suppression of increased vascular permeability reflected in the decreased paw volume and Evans blue dye
leakage. It appeared that this permeability modulation by AEBO also involved the reduction of biochemical
mediators such as NO and VEGF. We considered that the active principle contained in the aqueous extract may play
a role in its anti-inflammatory activity. Whether or not it acts by stabilizing mast cells remains to be elucidated.