Conclusion- ICU nurses’ knowledge on VAP prevention was adequate but their practice was found to be poor. No significant association between ICU training, level of education, years of working experience and knowledge. Practice of ICU nurses on VAP prevention was statistically associated with education level but not with ICU training and years of working experience. Hand washing, environment and equipment cleanness during ETS and oral care was inadequate therefore knowledge of ICU nurses on VAP prevention does not necessarily reflect adequate practical skills.