1. Introduction
As other nonsteroidal anti-inflammatory drugs
(NSAID), diclofenac [2-(2%,6%-dichloroanilino)-
phenylacetic acid] is a fenamate derivative displaying
anti-inflammatory, analgesic and
antipyretic activity, showing a potent reversible
inhibition of prostaglandin synthesis both in vivo
and in vitro [1]. It is used in the treatment of
many diseases, such as rheumatoid arthritis, osteoarthritis,
ankylosing spondylitis, nonarticular
rheumatism and sport injuries [1]. The side effects
that have been reported are gastrointestinal effects,
headache, dizziness, skin rushes, edema and
hepatic and renal damage. In some cases, gastric
or intestinal ulcers, bleeding ulcers, heart failure
and sight trouble could also be produced.