We analyzed the impact that personal variables (optimism and emotional intelligence) have on adherence and quality of life in people with allergies. We also analyzed its relationship with socio-demographic variables. Sixty people (50% men) who suffer from allergies and that they have a drug treatment (mean age 34.46, SD= 9.84, range: 20-50 years) completed a battery of instruments measuring the variables of interest. Our results show that optimism predicts adherence and quality of life, whereas understanding of emotions (a component of emotional intelligence) predicts adherence and quality of life (physical and global). Furthermore, three are significant effects of the interaction between optimism and emotional intelligence. There are no differences by sex, age and level of studies.