The membrane is the most probable site of disruption (29).
High-hydrostatic pressure treatments can alter membrane
functionalities such as active transport or passive permeability
and therefore perturb the physicochemical balance of the cell
(43). There is a considerably evidence that pressure tends to
loosen the contact between attached enzymes and membrane
surface as a consequence of the changes in the physical state of
lipids that control enzyme activity. The leakage of intracellular
constituent through the permeabilized cell membrane is the
most direct reason for cell death after high pressure treatment
(27).