• Abnormalities in apolipoprotein E (apoE4) which binds amyloid-beta • Excessive influx of calcium due to abnormal activation of N-methyl – D – aspartate receptors • Other chromosomal abnormalities linked to early and late onset FAD
• Abnormalities in apolipoprotein E (apoE4) which binds amyloid-beta • Excessive influx of calcium due to abnormal activation of N-methyl – D – aspartate receptors • Other chromosomal abnormalities linked to early and late onset FAD