To examine whether post-EAMD intervention with carbohydrate
supplements could normalize the menstrual cycle and
reverse the exercise-induced ovary dysfunction, we treated
EAMD rats with glucose and oligosaccharide for 3 weeks. Rats
treated with carbohydrate supplements after EAMD showedsame menstrual cycles as rats from groups C and R, suggesting
that extra energy intakes successfully restored the ovarian
function in adult female rats. Furthermore, rats received
glucose and oligosaccharide supplements reversed the EAMDinduced
mitochondria morphology injuries. We found a slight
increase in number of mitochondria and a significant recovery
of exercise-induced mitochondria impairment in rats treated
with oligosaccharide and glucose, respectively. Our data also
showed a significant reduction of serum progesterone level in
rats with glucose intake compared to controls, while no differences
in 17b-estradiol levels among rats from groups C, R,
O, and G. While the reason of failing to restore EAMD-induced
attenuation of progesterone in rats received post-EAMD
glucose supplement needs further investigation, studies found
an insulin sensitivity increases in exercise women,32 which
might counter the effect of glucose supplement in EAMD.