ranked in position 1 in the database search were considered, if the corresponding protein was identified in three technical replicates within each experimental group. Functional protein interaction analysis was performed with Search Tool for the Retrieval of Interacting Genes (STRING), i.e. a database of known and predicted protein interactions [20]. Resulted networks were clustered based on the Markov cluster algorithm (MCL), disconnected nodes were removed and resulted clusters were manually annotated. It is important to note that STRING protein– protein interaction analysis, performed in the current study, relay on the knowledge databases which are summing up reported physical interactions (proteins binding) as well as neighborhood in