Paracoccidioides is a thermally dimorphic fungus. Although it has been isolated from soil and digestive tract of some animals, its natural habitat remains unknown. It mostly resides in soil which is humid and rich in proteins. It has been cultivated from fruit bats and armadillos. While the epidemiology of the infections due to Paracoccidioides has not been fully clarified, most infections with Paracoccidioides have been reported from Central and South America, particularly from Brazil, Venezuela, and Colombia. Geographic discrimination of the strains have recently been possible by randomly amplified polymorphic DNA analysis [363] [462, 2107, 2144, 2202].