despite the rather unphysiologically high Ca2 + concentration. A 10-ms-pulse to − 150 mV elicited a transient capacitive inward current that decayed within 1–2 ms (Fig. 4A), whereas a pulse to − 600 mV command voltage induced pore formation and, in turn, inward current increasing with time that was superimposed on the capacitive current spike (compare e.g. [8]). Note that the effective voltage drop (Fig. 4B, top panel, continuous trace) deviated considerably from the command voltage (dotted line) due to a voltage drop at the access resistance [8].