The concentration–time curve of NiCl2 was shown in Fig. 2 following i.p. with NiCl2 and
CdCl2. NiCl2 has not been found in blood before 2.4 h; the concentration reached maximum
at 5 h and declined quickly after 5 h. Because absorption of NiCl2 was delayed, the data
cannot be analyzed by 3p97; the corresponding kinetic parameters were not estimated.
Excretion of Rats 24 h Post i.p. with NiCl2 or NiCl2 + CdCl2
The results of the excretion study were presented in Table 2. The excretion of NiCl2 was
very rapid; 89.91% of the injected NiCl2 were eliminated by urine 24 h post i.p. with NiCl2
only. The excretion value was 36.91% by urine within 3 h. Excretion rate of NiCl2 was
lower from 3 to 6 h; it was just 14.05% by urine. In addition, 38.95% of NiCl2 were
eliminated by urine from 0 to 18 h; fecal excretion were very low (4.64%) 24 h post.
Injected NiCl2 (84.12%) was excreted by urine 24 h post i.p. with NiCl2 + CdCl2; in
contrast, fecal excretion were just 6.64% within 3 h. most NiCl2 (45.57%) were eliminated
by urine from 3 to 6 h. The later excretions (from 6 to 24 h) between the two groups have
shared the similar value, which were 38.95% and 31.91%, respectively.
NiCl2 Distribution in Tissues of Rats Post i.p. with NiCl2 and NiCl2 + CdCl2 at Different
Time Points
After i.p. with NiCl2 at 3 h, nickel distributions in rat organs were shown in Fig. 3. The
results showed that NiCl2 arrived at almost all organs except blood. The concentration was