The most significant antidiabetic activity was observed with
metformin at dose level of 50 mg/kg i.p. While comparing with
the diabetic control, amongst the extract and its fractions, CCM
extract and CCES fraction have significantly lowered the elevated
blood glucose levels. The most prominent antidiabetic activity was
observed by CCES fraction (64.5%) at dose level of 400 mg/kg, per
oral after 24 h. While the CCAS fraction marginally lowered the
blood glucose level in both the selected doses (Fig. 1) and CCAIS
fraction was found to be inactive at the dose level of 400 mg/kg of
body weight (data not shown). Results obtained from experiment
revealed that extract and its fractions have shown antidiabetic
activity in decreasing order of CCES > CCM > CCAS > CCAIS.