Nagato was raised in the outskirts of Amegakure; Karin apparently lived in Kusagakure for a time; Kushina in Konoha, who had a son, Naruto, who years later has children of his own with his wife Hinata Hyūga: Boruto and Himawari. As a result, this has strengthened the Uzumaki clan's familial relation to the Hyūga Clan (the descendants of Asura's uncle, Hamura Ōtsutsuki).