Splenda (sucralose): The yellow packets are 600 times sweeter than sugar and have zero calories per packet. Splenda can be used in baking but you may need to make some adjustments in your measurements, as sucralose is a more vigorous sweetener than white sugar. However, a topic of debate is the fact that the sucralose molecule contains chlorine. While chlorine is naturally present in many of the foods we already eat, LiveStrong.com articulates some health concerns when chlorine bonds to carbon, creating a chemical known as chlorocarbon. Chlorocarbons are found in insecticides, disinfectants and bleach, says Dr. James Bowmen, researcher and biochemist.