After excluding other infectious ocular diseases and systemic inflammatory disease, VKH was considered. A regimen of 1.5 mg/kg prednisone per day was initiated, and tapered to a weekly dose. The inflammation in the patient’s right eye was improved, and the BCVA recovered to 20/50. He continued to be seen by his corneal specialist for follow-up on the left eye. A regular B-scan was performed, and atrophy of the left eyeball was detected 2 months later. Upon removal of the left eyelid sutures, corneal perforation with a prolapsed iris was found (Figure 4). Afterwards, the inflammation of the right eye reoccurred, and the diagnosis was revised to SO. The patient underwent an enucleation procedure on the left eye, and a massive prednisolone regimen was initiated, and then tapered slowly over one year. Pathological results showed diffuse epithelioid cells, polymorphonuclear giant cells, and lymphocyte infiltration in the uveal tissue (Figure 5). SO was confirmed.