This paper would not have been possible without the leadership of Clifford
Kay, who established and ran the study for its first 26 years, or the many
generalpractitionerswhocontributeddata.WealsothankAileenMurphyfor
databaseadministrationsupportandSivasubramaniamSelvarajwhowrote
most of the programming in Stata.
Contributors: PCH had the original idea, advised on and checked the
analyses, and wrote the first and subsequent drafts of the paper. LI and
AME had responsibility for updating the database with information on
deaths. LI and VA checked the data extractions and analyses. TM was
responsible for data analysis. AJL, with AME, checked the validity of the
program used to analyse the data. VA maintained the study database and
extracted data for analysis. All authors contributed to the scientific
development of the paper, commented on successive drafts, and agreed
to the final manuscript. PCH is the guarantor.
Funding: The study received funding from the Royal College of General
Practitioners, Medical Research Council, Imperial Cancer Research Fund,
British Heart Foundation, Cruden Foundation, Schering AG, Schering
Health Care, Wyeth Ayerst International, Ortho Cilag, and Searle. None of
the funders had a role in the data collection, analysis, or interpretation or
in the writing of this paper.
Competing interests: The Centre of Academic Primary Care has received
payments from Schering Plough and Wyeth Pharmaceutical for lectures
and advisory board work provided by PCH.
Ethical approval: The study was established before the introduction of
research ethics committees in the UK. Even so, procedures were used to
maintain the confidentiality of women. Correspondence between
participating doctors and the study, and between the NHS central
registries and the study, used a unique study number, the key to which
only the general practitioners knew.
Data sharing: No additional data available
This paper would not have been possible without the leadership of CliffordKay, who established and ran the study for its first 26 years, or the manygeneralpractitionerswhocontributeddata.WealsothankAileenMurphyfordatabaseadministrationsupportandSivasubramaniamSelvarajwhowrotemost of the programming in Stata.Contributors: PCH had the original idea, advised on and checked theanalyses, and wrote the first and subsequent drafts of the paper. LI andAME had responsibility for updating the database with information ondeaths. LI and VA checked the data extractions and analyses. TM wasresponsible for data analysis. AJL, with AME, checked the validity of theprogram used to analyse the data. VA maintained the study database andextracted data for analysis. All authors contributed to the scientificdevelopment of the paper, commented on successive drafts, and agreedto the final manuscript. PCH is the guarantor.Funding: The study received funding from the Royal College of GeneralPractitioners, Medical Research Council, Imperial Cancer Research Fund,British Heart Foundation, Cruden Foundation, Schering AG, ScheringHealth Care, Wyeth Ayerst International, Ortho Cilag, and Searle. None ofthe funders had a role in the data collection, analysis, or interpretation orin the writing of this paper.Competing interests: The Centre of Academic Primary Care has receivedpayments from Schering Plough and Wyeth Pharmaceutical for lecturesand advisory board work provided by PCH.Ethical approval: The study was established before the introduction ofresearch ethics committees in the UK. Even so, procedures were used tomaintain the confidentiality of women. Correspondence betweenparticipating doctors and the study, and between the NHS centralregistries and the study, used a unique study number, the key to whichonly the general practitioners knew.Data sharing: No additional data available
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