Increased capillary fragility – brought about by a strong immune complex reaction the produce toxic substance like histamine, serotonin and bradykinin which damages the capillary wall à in an attempt to repair lesions, clotting occurs à DISSEMINATED INTRAVASCULAR COAGULATION
Increased capillary permeability – loss of plasma from intravascular space
Thrombocytopenia – acute excessive consumption of platelets due to generalized intravascular clotting
Decreased blood coagulation factors – initiated by lesions in the capillary wall