The concept is based on the genes coding for the synthesis of small mediator molecules that are up-regulated during inflammation.For example, genes that are proinflammatory are type II phospholipase (PL) A2, cyclooxygenase (COX)-2, and inducible NO synthase.
These genescode for enzymes that increase the synthesis of platelet-activating factor and leukotrienes, prostanoids,and NO.