In contrast, testosterone replacement therapy in otherwise
healthy elderly men showed no improvement in muscle
strength in two randomised, placebo-controlled trials with
a 36 month [6] and 6 month duration of testosterone or
placebo treatment, respectively [12].
Testosterone is not only an important regulator of muscle
and fat mass but also plays also an important role in the
maintenance of bone density in men. Hypogonadism is
a common cause of osteoporosis and rapid bone loss is