The chemical affinity for both
neutral lipids and polar lipids is approximately linearly related to the
affinity for octanol (Hendriks et al., 2005). Substance affinity for
proteins can also be related to the octanol–water partition coefficient,
but the relationship is less than linear due to the polar nature of
proteins (Hendriks et al., 2005). The blood–air partition coefficient
can thus be estimated based on the physiological characteristics of
blood and the affinity for these different blood components divided by
the temperature-corrected air–water partition coefficient (Eq. (5)).